How and where to order Cyclosporine (Neoral, Restasis, Atopica) 25 mg, 50 mg, 100 mg capsules or tablets, 0.05% ophthalmic solution on the National Marrow Donor Program Research website:
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|Forms:||Neoral tablets 25 mg, 50 mg, 100 mgGeneric Restasis emulsion ophthalmic 0.05% 3 mlBrand Restasis emulsion ophthalmic 0.05% 0.4 mlAtopex (Ichmune C) 25 mg, 50 mg, 100 mg pills for dogsCyclosporine 25 mg capsules or tabletsCyclosporine eye drops (ophthalmic solution) 0.05% 3 ml
|Quantity:||6-90 pills1-90 bottles
|Type:||Cyclosporine brand for humans and for dogsNeoral genericRestasis brandRestasis genericAtopica genericAtopex genericIchmune C brand
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Cyclosporine (USAN), also known as Ciclosporin (INN) and Cyclosporin (BAN) - trade names include Atopica, Neoral, Restasis, Arpimune, Biosporin, Cyclaid, Cyclophil-ME, Deximune, Equoral, Gengraf, Ikervis, Neoral-Sandimmun, Optimmune, Panimun Bioral, Psorid, Restasis Multidose, Sandimmun Neoral, Sandimmun Optoral, Sandimmune, Sporimune, Teva-Cyclosporine is an immunosuppressant drug and ophthalmological medication from calcineurin inhibitors pharmacological group. This medicine is used for the treatment of dry eye (keratoconjunctivitis sicca), Sjogren's syndrome, persistent nummular keratitis, adenoviral keratoconjunctivitis, posterior or intermediate uveitis, iridocyclitis; for preventing the rejection of organ transplants (heart, kidney, liver, skin, bone marrow, pancreas, small intestine, lung); to treat rheumatoid arthritis and related diseases, psoriasis, atopic dermatitis, dermatopolymyositis, systemic lupus erythematosus, Kimura disease, pyoderma gangrenosum, Crohn's disease, chronic autoimmune urticaria (hives), acute systemic mastocytosis, acute severe ulcerative colitis, nephrotic syndrome, graft-versus-host disease in bone-marrow transplantation.
In veterinary medicine Cyclosporine is indicated for the therapy of skin allergies, atopic dermatitis, sebaceous adenitis, pemphigus foliaceus, inflammatory bowel disease, anal furunculosis, myasthenia gravis, immune-mediated hemolytic anemia in dogs, cats, other pets and animals. As an ophthalmological drug it helps to increase the eyes' natural ability to produce tears which moisten and protect the eyes from infections.
As an immunosuppressant medication Cyclosporine works by decreasing the immune system's response to a transplanted organ.
Mycophenolic Acid (CellCept)
Tacrolimus (Prograf, Protopic)
Pharmacological and medical categories:
Disease modifying antirheumatic drugs (DMARD)
Veterinary, pet meds
L - Antineoplastic and immunomodulating agents
L04 - Immunosuppressants
L04A - Immunosuppressants
L04AD - Calcineurin inhibitors
L04AD01 - Cyclosporine
S - Sensory organs
S01 - Ophthalmologicals
S01X - Other Ophthalmologicals
S01XA - Other Ophthalmologicals
S01XA18 - Cyclosporine
Other benign neoplasms of connective and other soft tissue - D21
Benign neoplasm of connective and other soft tissue, unspecified - D21.9
Other neoplasms of uncertain behavior of lymphoid, hematopoietic and related tissue - D47
Other disorders involving the immune mechanism, not elsewhere classified - D89
Graft-versus-host disease - D89.81
Systemic mastocytosis - D47.02
Hemolytic anemias - D55-D59
Myasthenia gravis and other myoneural disorders - G70
Keratitis - H16
Keratoconjunctivitis - H16.2
Keratoconjunctivitis sicca, not specified as Sjogren's - H16.22
Macular keratitis - H16.11
Iridocyclitis - H20
Chorioretinal inflammation - H30
Disorders of globe - H44
Crohn's disease [regional enteritis] - K50
Ulcerative colitis - K51
Abscess of anal and rectal regions - K61
Anal abscess - K61.0
Acute lymphadenitis - L04
Pemphigus - L10
Pemphigus foliaceous - L10.2
Atopic dermatitis - L20
Psoriasis - L40
Urticaria - L50
Pyoderma gangrenosum - L88
Rheumatoid arthritis with rheumatoid factor - M05
Systemic lupus erythematosus - M32
Dermatopolymyositis - M33
Other systemic involvement of connective tissue - M35
Sicca syndrome [Sjogren] - M35.0
Nephrotic syndrome - N04
Transplanted organ and tissue status - Z94
Indications and usage:
Kidney, liver, and heart transplantation: Neoral (Cyclosporine) is indicated for the prophylaxis of organ rejection in kidney, liver, and heart allogeneic transplants. This medication has been used in combination with azathioprine and corticosteroids.
Rheumatoid arthritis: Cyclosporine (Neoral) capsules are indicated for the treatment of patients with severe active, rheumatoid arthritis where the disease has notadequately responded to methotrexate. This medicine can be used in combination with methotrexate in rheumatoid arthritis patients who do not respond adequately to methotrexate alone.
Psoriasis: Neoral is indicated for the treatment of adult, nonimmunocompromisedpatients with severe (i.e., extensive and/or disabling), recalcitrant, plaque psoriasis who have failed to respond to at least one systemic therapy (e.g., PUVA, retinoids, or methotrexate) or in patients for whom other systemic therapies are contraindicated, or cannot be tolerated. While rebound rarely occurs, most patients will experience relapse with cyclosporine as with other therapies upon cessation of treatment.
Restasis (Cyclosporine) eye drops are a calcineurin inhibitor immunosuppressant indicated to increase tear production in patients whose tear production is presumed to be suppressed due to ocular inflammation associated with keratoconjunctivitis sicca. Increased tear production was not seen in patients currently taking topical anti-inflammatory drugs or using punctal plugs.
Dosage and administration:
Neoral (Cyclosporine) soft gelatin capsules: The daily dose of should always be given in two divided doses (BID). It is recommended that Neoral be administered on a consistent schedule with regard to time of day and relation to meals. Grapefruit and grapefruit juice affect metabolism, increasing blood concentration of cyclosporine, thus should be avoided.
Instill one drop of Restasis (Cyclosporine) ophthalmic emulsion twice a day in each eye approximately 12 hours apart.
Dosage forms and strengt:
Neoral soft gelatin capsules (Cyclosporine capsules, USP) modified: 10 mg, 25 mg, 50 mg, 100 mg.
Restasis (Cyclosporine) ophthalmic emulsion 0.5 mg/mL.
There is a minimal experience with Neoral pills overdosage. Forced emesis and gastric lavage can be of value up to 2 hours after administration of cyclosporine. Transient hepatotoxicity and nephrotoxicity may occur which should resolve following drug withdrawal. Oral doses of cyclosporine up to 10 g (about 150 mg/kg) have been tolerated with relatively minor clinical consequences, such as vomiting, drowsiness, headache, tachycardia and, in a few patients, moderately severe, reversible impairment of renal function. However, serious symptoms of intoxication have been reported following accidental parenteral overdosage with cyclosporine in premature neonates. General supportive measures and symptomatic treatment should be followed in all cases of overdosage. Neoral (Cyclosporine) is not dialyzable to any great extent, nor is it cleared well by charcoal hemoperfusion. The oral dosage at which half of experimental animals are estimated to die is 31 times, 39 times, and >54 times the human maintenance dose for transplant patients (6mg/kg; corrections based on body surface area) in mice, rats, and rabbits.
General: Neoral (Cyclosporine) is contraindicated in patients with a hypersensitivity to cyclosporine or to any of the ingredients of the formulation.
Rheumatoid arthritis: patients with abnormal renal function, uncontrolled hypertension, or malignancies should not receive Neoral.
Psoriasis: patients who are treated with Neoral capsules or tablets should not receive concomitant PUVA or UVB therapy, methotrexate or other immunosuppressive agents, coal tar or radiation therapy. Psoriasis patients with abnormal renal function, uncontrolled hypertension, or malignancies should not receive Neoral.
Contraindications for Restasis (Cyclosporine) eye drops: hypersensitivity.
Warnings and precautions:
Only physicians experienced in management of systemic immunosuppressive therapy forthe indicated disease should prescribe Neoral (Cyclosporine) pills. At doses used in solid organ transplantation, only physicians experienced in immunosuppressive therapy and management of organ transplant recipients should prescribe Neoral. Patients receiving the drug shouldbe managed in facilities equipped and staffed with adequate laboratory and supportive medical resources. The physician responsible for maintenance therapy should have complete information requisite for the follow-up of the patient.
Cyclosporine capsules, a systemic immunosuppressant, may increase the susceptibility to infection and the development of neoplasia. In kidney, liver, and heart transplant patients Neoral may be administered with other immunosuppressive agents. Increased susceptibility to infection and the possible development of lymphoma and other neoplasms may result from the increase in the degree of immunosuppression in transplant patients.
Neoral soft gelatin capsules (cyclosporine capsules, USP) modified and Neoral oral solution (cyclosporine oral solution, USP) modified have increased bioavailability in comparison to Sandimmune soft gelatin capsules (cyclosporine capsules, USP) and Sandimmune oral solution (cyclosporine oral solution, USP). Neoral and Sandimmune are not bioequivalent and cannot be used interchangeably without physician supervision. For a given trough concentration, cyclosporine exposure will be greater with Neoral than with Sandimmune. If a patient who is receiving exceptionally high doses of Sandimmune is converted to Neoral, particular caution should be exercised. Cyclosporine blood concentrations should be monitored in transplant and rheumatoid arthritis patients taking Neoral to avoid toxicity due to high concentrations. Dose adjustments should be made in transplant patients to minimize possible organ rejection due to low concentrations. Comparison of blood concentrations in the published literature with blood concentrations obtained using current assays must be done with detailed knowledge of the assay methods employed.
Restasis (Cyclosporine) ophthalmic solution: to avoid the potential for eye injury and contamination, be careful not to touch the vial tip to your eye or other surfaces.
Adverse reactions, side effects:
Kidney, liver, and heart transplantation: the principal adverse reactions of cyclosporine systemic therapy are renal dysfunction, tremor, hirsutism, hypertension, and gum hyperplasia.
Postmarketing experience, kidney, liver and heart transplantation: hepatotoxicity, increased risk of infections, headache, including migraine, pain of lower extremities.
Rheumatoid arthritis: the principal adverse reactions associated with the use of cyclosporine in rheumatoid arthritis are renal dysfunction, hypertension, headache, gastrointestinal disturbances, and hirsutism/hypertrichosis.
Psoriasis: the principal adverse reactions associated with the use of cyclosporine in patients with psoriasis are renal dysfunction, headache, hypertension, hypertriglyceridemia, hirsutism/hypertrichosis, paresthesia or hyperesthesia, influenza-like symptoms, nausea/vomiting, diarrhea, abdominal discomfort, lethargy, and musculoskeletal or joint pain.
Postmarketing experience, psoriasis: cases of transformation toerythrodermic psoriasis or generalized pustular psoriasis upon either withdrawal or reduction of cyclosporine in patients with chronic plaque psoriasis have been reported.
The most common adverse reaction following the use of Restasis (Cyclosporine) eye drops was ocular burning.
To report suspected side effects of Neoral contact Novartis, of Restasis - Allergan pharmaceutical company, or your local FDA.
When diclofenac or methotrexate was coadministered with cyclosporine in rheumatoid arthritis patients, the AUC of diclofenac and methotrexate, each was significantly increased. No clinically significant pharmacokinetic interactions occurred between cyclosporine and aspirin, ketoprofen, piroxicam, or indomethacin.
Patient counseling information:
Restasis Multidose (Cyclosporine) ophthalmic solution
Handling the container: advise patients to not allow the tip of the bottleto touch the eye or any surface, as this may contaminate the emulsion. Advise patients to not touch the bottletipto theireyeto avoid the potential for injury to the eye.
Use with contact lenses: Restasis Multidose should not be administered while wearing contact lenses. Patients with decreasedtear production typically should not wear contact lenses. Advise patients that if contact lenses are worn, they should be removed prior to the administration of the emulsion. Lenses may be reinserted 15 minutes following administration of Restasis Multidose ophthalmic emulsion.
Administration: advise patients to read the instructions for use for detailed first-time use instructions.
C - Australia
C - United States (Risk cannot be ruled out)
Salts and other forms:
Cyclosporine A Modified
Synonyms, international and chemical names:
Ciclosporina A Modificada
Brands, generics, trade names:
Arpimune - Pascual Laboratories, RPG Life Sciences, Zuellig Pharma
Atopica - Novartis
Atopica for Dogs - Novartis, Elanco
Atopica for Cats - Novartis, Elanco
Atoplus - Novartis
Biosporin - Biotoscana Farma
Cicloral - Hexal, Salutas Pharma
Ciclosporin - Hexal, Mylan, Sandoz, Teva
Ciclosporina - Germed Farmaceutica, Medifarma Laboratorios, Teva
Ciclosporine - Actavis, Pharmachemie, Sandoz
Ciklosporin - Alkaloid, IVAX
Cipol-N - Chong Kun Dang Pharmaceutical, Hoffman Health Pakistan, SPS Medical
Ciqorin - Teva
Cyclaid - Apotex, Medis International
Cyclavance - Virbac
Cyclomune - Sun Pharmaceutical Industries, Avesta
Cyclophil-ME - Biocon
Cyclosporine - Sandoz, Teva, Watson Pharmaceuticals
Deximune - Dexcel Pharma, Dexxon, Cherubino, Medicem
Equoral - Teva, Chile Laboratorios, Duy Tan Pharma, IVAX, Pliva, R.X. Company
Gengraf - Abbott, AbbVie
Hydroeyes - Pharmika India
Ikervis - Santen Pharmaceutical, Excelvision
Nano Tears - Sunways India
Neoral - Novartis
Neoral-Sandimmun - Novartis
Opticare - Cipla
Optimmune - Intervet, Bayer, Essex-Tierarznei, Merck
Optimmune-Canis - Intervet, Schering-Plough
Panimun Bioral - Panacea Biotec, Ecolity
Psorid - Biocon
Restasis - Allergan
Restasis Multidose - Allergan
Sandimmun Neoral - Novartis
Sandimmun Optoral - Novartis
Sandimmune - Novartis, Catalent, Sandoz
Sporimune - Dechra Veterinary Products, Dr. E. Graub, Le Vet Pharma, Vetcare
Teva-Cyclosporine - Teva
Visiocare - Veritas Pharma
Here is a list of popular medications containing cyclosporine as a main active pharmaceutical ingredient; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:
|Trade name of the drug
||Pharmaceutical forms and doses
||Capsules; Oral; Cyclosporine 10 mgCapsules; Oral; Cyclosporine 25 mgCapsules; Oral; Cyclosporine 50 mgCapsules; Oral; Cyclosporine 100 mg
||Capsules; Oral; Cyclosporine 10 mgCapsules; Oral; Cyclosporine 25 mgCapsules; Oral; Cyclosporine 50 mgCapsules; Oral; Cyclosporine 100 mgSolution; Oral; Cyclosporine 100 mg / ml
||NovartisEuro RegistratieKosei PharmaO.P.D. LaboratoriesPharma-XL
||Emulsion; Ophthalmic; Cyclosporine 0.05%
||AllerganDKSHMaxim PharmaceuticalsThe Glory MedicinaZuellig Pharma
||Capsules; Oral; Cyclosporine 10 mgCapsules; Oral; Cyclosporine 25 mgCapsules; Oral; Cyclosporine 50 mgCapsules; Oral; Cyclosporine 100 mgInjectable; Infusion; Cyclosporine 50 mg / mlInjectable; Injection; Cyclosporine 50 mg / mlInjectable; Injection; Cyclosporine 100 mg / mlSolution; Oral; Cyclosporine 100 mg / mlSyrup; Oral; Cyclosporine 100 mg / ml
||NovartisBiochemieCatalentDelpharmDKSHEurim-PharmEuro RegistratieFarlicFarmagonFour StarHaemato PharmInstitute of Pharmaceutical Research and TechnologyR.P. SchererZuellig Pharma
Ciclosporin main article on Wikipedia: https://en.wikipedia.org/wiki/Ciclosporin
Cyclosporine compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Cyclosporine
Cyclosporine medicine on DrugBank: https://go.drugbank.com/drugs/DB00091
Cyclosporins group on DrugBank: https://go.drugbank.com/categories/DBCAT000198
Cyclosporine FAQ on MedlinePlus (revised 12/15/2015): https://medlineplus.gov/druginfo/meds/a601207.html
Cyclosporine Ophthalmic FAQ on MedlinePlus (revised 10/15/2018): https://medlineplus.gov/druginfo/meds/a604009.html
Cyclosporine Injection FAQ on MedlinePlus (revised 12/01/2009): https://medlineplus.gov/druginfo/meds/a684054.html
Cyclosporine Apotex capsules drug label info on DailyMed (revised January 22, 2020): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Neoral (Cyclosporine) capsules and oral solution drug label info on DailyMed (revised June 13, 2020): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Atopica (Cyclosporine) capsules drug label info on DailyMed (revised July 19, 2016): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Restasis (Cyclosporine) ophthalmic emulsion drug label info on DailyMed (revised July 1, 2017): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Cyclosporine containing drugs on Drugs-About.com: https://drugs-about.com/ing/cyclosporine.html
Cyclosporine for sale on Pharma Doctor: https://pharma-doctor.com/cyclosporine.html
Neoral (Cyclosporine) capsules and oral solution official prescribing information from the U.S. FDA (revised September 2009): https://www.accessdata.fda.gov/drugsatfda_docs/label...
Neoral (Cyclosporine) capsules and oral solution prescribing information from Novartis pharmaceutical company (revised March 2015): https://www.novartis.us/sites/www.novartis.us/files/neoral.pdf
Sandimmun Neoral (Cyclosporine) soft capsules 10 mg, 25 mg, 50 mg, 100 mg product information from European Medicines Agency: https://www.ema.europa.eu/en/documents/...
Restasis (Cyclosporine) ophthalmic emulsion 0.05% official prescribing information and instructions for use from the U.S. FDA (revised 10/2016): https://www.accessdata.fda.gov/drugsatfda_docs/label...
Restasis (Cyclosporine) ophthalmic emulsion 0.05% and Restasis MultiDose official prescribing information and instructions for use from Allergan (revised 07/2017): https://media.allergan.com/actavis/actavis/media/...
Restasis eye drops and Restasis MultiDose (Cyclosporine Ophthalmic Emulsion) 0.05% official website: https://www.restasis.com/
Atopica for dogs (Cyclosporine) capsules, USP modified, official website: https://us.atopica.com/
Neoral (Cyclosporin) soft gelatin capsules 10 mg, 25 mg, 50 mg, 100 mg patient information leaflet from Medicines.org.uk (revised January 2021): https://www.medicines.org.uk/emc/files/pil.1034.pdf
Neoral (Cyclosporin) oral solution patient information leaflet from Medicines.org.uk (revised January 2021): https://www.medicines.org.uk/emc/files/pil.5300.pdf
Revised: June 2021
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